Memantine is used to treat moderate to severe Alzheimer's disease. Memantine is not a cure for Alzheimer's disease but it can help people with the disease. Memantine will not cure Alzheimer's disease, and it will not stop the disease from getting worse.

This medicine is available only with your doctor's prescription.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

You may take this medicine with or without food.

Swallow the extended-release capsules whole. Do not break, crush, or chew them.

If you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of soft food such as applesauce. Stir this mixture well and swallow it without chewing.

For patients taking the oral liquid:

• Remove the oral dosing syringe along with the cap and plastic tube from the bag and attach to tube to the cap.
• Open the child-resistant cap on the bottle by pushing down on the cap while turning the cap counter-clockwise (to the left) and remove the cap and seal from the bottle.
• Insert the plastic tube fully into the bottle and screw the cap tightly onto the bottle by turning the cap clockwise (to the right).
• Keeping the bottle upright on the table, remove the lid to uncover the opening on the top of the cap. With the plunger fully depressed, insert the tip of the syringe firmly into the opening of the cap.
• While holding the syringe, gently pull the plunger of the syringe up to draw medicine into the syringe.
• Remove the syringe from the cap opening. Invert the syringe (point tip upwards) and slowly press the plunger to a level that pushed out any large air bubbles that may be present. Keep the plunger in this position.
• Re-insert the tip of the syringe into the cap opening. While holding the syringe, continue to gently pull out the plunger until the bottom of the black ring of the plunger reaches the appropriate mark on the syringe that corresponds to the dose prescribed.
• Remove the syringe from the bottle and swallow the oral solution directly from the syringe. Do not mix with any other liquid.
• After use, reseal the bottle by snapping the attached lid closed.
• Rinse the empty syringe by inserting the open end of the syringe into a glass of water, pulling the plunger out to draw in water, and pushing the plunger in to remove the water. Repeat several times. Allow the syringe to air dry.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

dizziness

headache

nervousness

pounding in the ears

rapid weight gain

slow or fast heartbeat

tingling of the hands or feet

unusual weight gain or loss

Incidence not known

Abdominal or stomach pain

agitation

black, tarry stools

bleeding gums

blistering, peeling, or loosening of the skin

blood in the urine or stools

chest pain

coma

constipation

continuing vomiting

convulsions

dark-colored urine

decreased urine output

depression

fainting

fast, pounding, or irregular heartbeat or pulse

general feeling of tiredness or weakness

high fever

high or low blood pressure

hostility

increased sweating

indigestion

infection from breathing foreign substances into the lungs

itching

lethargy

light-colored stools

lip smacking or puckering

loss of consciousness

muscle twitching

no blood pressure

no breathing

no pulse

numbness or tingling in the face, arms, or legs

pain in the stomach, side, or abdomen, possibly radiating to the back

pain or swelling in the arms or legs without any injury

pain, tension, and weakness upon walking that subsides during periods of rest

pinpoint red spots on the skin

pounding, slow heartbeat

puffing of the cheeks

rapid or worm-like movements of the tongue

rapid weight gain

recurrent fainting

red irritated eyes

red skin lesions, often with a purple center

seizures

severe constipation

severe headache

severe muscle stiffness

severe vomiting

sores, ulcers, or white spots in the mouth or on the lips

stupor

sudden severe weakness

swelling of the face, ankles, or hands

total body jerking

trouble with speaking or walking

troubled breathing

twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

uncontrolled chewing movements

unusual bleeding or bruising

unusually pale skin

vomiting

yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Confusion

Less common

Anxiety

back pain

bladder pain

bloody or cloudy urine

change in walking and balance

chills

clumsiness or unsteadiness

cough producing mucus

coughing

diarrhea

difficult, burning, or painful urination

difficulty with breathing

difficulty with moving

discouragement

dry mouth

fear

feeling sad or empty

fever

frequent urge to urinate

general feeling of discomfort or illness

hyperventilation

insomnia

irritability

joint pain

loss of appetite

loss of bladder control

loss of interest or pleasure

lower back or side pain

muscle pain or stiffness

nausea

nervousness

pain

pain in the joints

restlessness

seeing, hearing, or feeling things that are not there

shortness of breath

sleepiness or unusual drowsiness

sore throat

tightness in the chest

tiredness

trouble with concentrating

trouble with sleeping

unusual tiredness or weakness

vomiting

wheezing

Incidence not known

Burning feeling in the chest or stomach

burning, numbness, pain, or tingling in all fingers except smallest finger

cold sweats

cool pale skin

decreased interest in sexual intercourse

difficulty with swallowing

general feeling of discomfort or illness

heartburn

inability to have or keep an erection

increased hunger

large amounts of fat in the blood

loss in sexual ability, desire, drive, or performance

nightmares

shakiness

slurred speech

stomach cramps

stomach upset

tenderness in the stomach area

watery or bloody diarrhea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.